ft- sers study of adriamycin - dna intraction
نویسندگان
چکیده
ft-sers (fourier transform surface enhanced raman scattering) of adriamycin and its complex with dna is reported. it is shown that in agreement with previous raman studies the interaction of adriamycin with dna takes place through an intercalation mechanism. the presence of a new band at 731 cm-1 suggests that ring d of adriamycin is not involved in the intercalation process.
منابع مشابه
FT- SERS Study of Adriamycin - DNA Intraction
FT-SERS (Fourier Transform Surface Enhanced Raman Scattering) of adriamycin and its complex with DNA is reported. It is shown that in agreement with previous Raman studies the interaction of adriamycin with DNA takes place through an intercalation mechanism. The presence of a new band at 731 cm-1 suggests that ring D of adriamycin is not involved in the intercalation process.
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Isotherms of the binding of the anthracycIine antibiotic, adriamycin (adriblastin), to DNA histone complexes was studied by means of spectroscopic analysis. The results indicated that: (a) binding of adriamycin to histones reduced the interaction of histones with DNA, (b) binding of the drug to DNA did not change the binding affinity of histone to DNA and, (c) in the explored binding range...
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Adriamycin is known to induce the formation of adducts with DNA when reacted under in vitro transcription conditions. The factors affecting the extent of adduct formation were examined in order to establish the critical components and optimal conditions required for the reaction, and to gain insight into the nature of the DNA-adduct complex. There was a strong dependence on reaction temperature...
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isotherms of the binding of the anthracyciine antibiotic, adriamycin (adriblastin), to dna histone complexes was studied by means of spectroscopic analysis. the results indicated that: (a) binding of adriamycin to histones reduced the interaction of histones with dna, (b) binding of the drug to dna did not change the binding affinity of histone to dna and, (c) in the explored binding range of r
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عنوان ژورنال:
iranian journal of chemistry and chemical engineering (ijcce)ناشر: iranian institute of research and development in chemical industries (irdci)-acecr
ISSN 1021-9986
دوره 22
شماره 1 2003
کلمات کلیدی
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